Technological advances in mosquito olfaction neurogenetics.

Abstract

Gene-editing technologies have revolutionized the field of mosquito sensory biology. These technologies have been used to knock in reporter genes in-frame with neuronal genes and tag specific mosquito neurons to detect their activities using binary expression systems. Despite these advances, novel tools still need to be developed to elucidate the transmission of olfactory signals from the periphery to the brain. Here, we propose the development of a set of tools, including novel driver lines as well as sensors of neuromodulatory activities, which can advance our knowledge of how sensory input triggers behavioral outputs. This information can change our understanding of mosquito neurobiology and lead to the development of strategies for mosquito behavioral manipulation to reduce bites and disease transmission.

Evidence profile

Study type

review

Text reviewed by the copilot

Full text is available

Publication status

published

Corrections or retractions

none

Conflict statement

Declaration of interests O.S.A. is a founder of Agragene, Inc. and Synvect, Inc. with an equity interest. The terms of this arrangement have been reviewed and approved by the University of California, San Diego in accordance with its conflict of interest policies. The remaining author declares no competing interests.

Topics and methods

Ask about this paper